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1 article(s) from Anderl, Jan

Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology

Jan Anderl,
Hartmut Echner and
Heinz Faulstich

Beilstein J. Org. Chem. 2012, 8, 2072–2084, doi:10.3762/bjoc.8.233

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Graphical Abstract

Figure 1: Chemical structure of phalloidin with the attachment site (R) used for conjugation to uptake-mediat...

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Figure 2: Cytotoxicity of phalloidin derivatives. NIH 3T3 mouse fibroblasts were incubated with various conce...

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Figure 3: n-Octanol/water distribution coefficients (log P_ow) of the hydrophobic phalloidin derivatives of Figure 2 p...

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Figure 4: (a) and (b): NIH 3T3 mouse fibroblasts were incubated with various concentrations of phalloidin and...

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Figure 5: Time course of uptake in NIH 3T3 cells of three phalloidin derivatives as measured by the cytotoxic...

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Figure 6: (a) Chemical structure of tetramethylrhodaminyl-phalloidin (3). (b) Growth inhibition of NIH 3T3 mo...

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Figure 7: Chemical structure of amanitin with attachment site for conjugation to internalization-mediating mo...

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Figure 8: NIH 3T3 mouse fibroblasts were incubated with various concentrations of α-amanitin and amanitin der...

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Full Research Paper

Published 27 Nov 2012

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